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HA is a major component of the vitreous body, and a key macromolecule in ophthalmology.It improves the effect of pilocarpine on miosis and facilitates delivery of gentamicin sulfate for the treatment of severe ocular infections.HA has been also used in assisting excimer laser surgeries for the correction of irregular astigmatism resulting from previous corneal refractive surgery, being able to cover depressions and irregularities from the previous surgery.Currently, a number of preparations, of varying molecular size HA chains, are available, including an HA and chondroitin sulfate combination, termed Viscoat.Its major use, however, is as a substitute or replacement for the vitreous fluid lost during procedures such as cataract surgery or lens placement.For many years, Healon, derived from rooster combs, manufactured initially by Biotics, Inc.This preparation was also used as a viscoelastic protector of the corneal endothelium during corneal transplantation.


Original text

HA is a major component of the vitreous body, and a key macromolecule in ophthalmology. Because of its viscoelastic properties, HA is used in a number of key ophthalmologic surgeries. Preparations of HA protect delicate eye tissues and provide space during surgical manipulations. Its major use, however, is as a substitute or replacement for the vitreous fluid lost during procedures such as cataract surgery or lens placement. For many years, Healon, derived from rooster combs, manufactured initially by Biotics, Inc. (Arlington, MA, USA) and later by Pharmacia, Sweden, was utilized for this purpose. This preparation was also used as a viscoelastic protector of the corneal endothelium during corneal transplantation. These cells do not regenerate after being damaged. Currently, a number of preparations, of varying molecular size HA chains, are available, including an HA and chondroitin sulfate combination, termed Viscoat. HA is found as a component of the normal ocular surface, in tears, lacrimal tissues, conjunctiva, and cornea, and is frequently used in the treatment of ocular surface disorders. The HA is used either alone, or in association with other molecules. In addition, hylans, a family of cross-linked high molar mass HA derivatives, have been used in artificial tear preparations for the treatment of dry eye disease, keratoconjunctivitis sicca. HÀ has been also used in assisting excimer laser surgeries for the correction of irregular astigmatism resulting from previous corneal refractive surgery, being able to cover depressions and irregularities from the previous surgery. HA is also useful as a vehicle for the delivery of topical treatments for the ocular surface. It improves the effect of pilocarpine on miosis and facilitates delivery of gentamicin sulfate for the treatment of severe ocular infections.


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