Lakhasly

?Nowadays, new drugs are mostly developed by the organic chemist working with a pharmacologist, increasingly from basic knowledge about key molecular targets.The Second World War was the impetus for accelerated research in pharmacology (the war time antimalarial program) in the U.S., and introduced strong analytical and synthetic chemical approaches.Usually some sort of biological screen is used to select among organic molecules for optimum pharmacological activity.Often in the past, this was based on folklore or intelligent observation (e.g. digitalis leaf, penicillin).It is of intellectual interest to know how drugs are discovered and developed.1.7.

 It is of intellectual interest to know how drugs are discovered and developed. Often in the past, this was
based on folklore or intelligent observation (e.g. digitalis leaf, penicillin). Nowadays, new drugs are
mostly developed by the organic chemist working with a pharmacologist, increasingly from basic
knowledge about key molecular targets. Usually some sort of biological screen is used to select among
organic molecules for optimum pharmacological activity.

1. Francois Magendie (1783-1855), a French physiologist laid down the dictum "Facts and facts alone are
   the basis of science." Experimental procedures with animals are the testing grounds for determination of
   drug action.


2. Claude Bernard (1813-1878), investigated the plant extract curare and proposed a site of action for this
   agent.


3. Rudolph Buchheim (1820-1879). In 1847 Buchheim established the first laboratory devoted to
   experimental pharmacology in the basement of his home in Dorpat which is known as the cradle of
   experimental pharmacology.


4. Oswald Schmiedeberg (1838-1921). In 1872 set up an institute of pharmacology in Strasbourg, France
   (Germany at that time) which became a mecca for students who were interest in pharmacological
   problems.


5. J.N. Langley (1852-1925 and Sir Henry Dale (1875-1968) pioneered pharmacology in England, taking a
   physiological approach.


6. John J. Abel (1857-1938) established the first chair of pharmacology in the U.S.A. (U. Michigan, 1891) after
   training in Germany. Able went to Johns Hopkins in 1893, and trained many U.S. pharmacologists. He is
   known as "The Father of American Pharmacology".


7. The Second World War was the impetus for accelerated research in pharmacology (the war time
   antimalarial program) in the U.S., and introduced strong analytical and synthetic chemical approaches.