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Fitch-Margoliash method
?The Fitch-Margoliash method groups people based on their genetic distance by using
a weighted least squares algorithm.To account for the higher inaccuracy in calculating
distances between distantly related sequences, the tree-building strategy gives greater
weight to tightly linked sequences.According to the distance linearity requirement, the anticipated value of the sum of
two branch distances must be equal to the expected value of the two branch length
sums.But the distance has to be changed
when the branch rates start to change at different speeds.?
Fitch-Margoliash method
▪ The Fitch-Margoliash method groups people based on their genetic distance by using
a weighted least squares algorithm. To account for the higher inaccuracy in calculating
distances between distantly related sequences, the tree-building strategy gives greater
weight to tightly linked sequences.
▪ According to the distance linearity requirement, the anticipated value of the sum of
two branch distances must be equal to the expected value of the two branch length
sums. A substitution matrix, such as the one produced by the Jukes-Cantor model of
DNA evolution, is used to make this correction. But the distance has to be changed
when the branch rates start to change at different speeds.
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