Lakhasly

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Function:

Providing support with both elasticity and firmness

Forming the earliest skeleton in the fetus

Cartilage is essential for the development and growth of long bones before and after birth

o Embryology of cartilage

i. Cartilage arises from stem cells, and some mesenchyme cells aggregate to form a blastema

ii. Blastema cells secrete cartilage matrix and are called chondroblastChondrocyte

Oval to round mature cartilage

It is chondroblast surrounded by matrix space(lacuna)

Young chondrocyte can divided but the adult chondrocyte cannot..


Original text

It is tough, rigid, elastic and resilient tissue


• Divided into three type according to the nature of its matrix


Hyaline cartilage CT


Fibro cartilage CT


Elastic cartilage CT


• It grow, repair and regenerates slowly in adult because:


It hasn't vascular (BV, lymphatic) and hasn't nerve cell


O2 supply and nutrient diffuse from the perichondrium to cartilage cell in the matrix


Adult chondrocyte stop dividing and with age, the cartilage tends to be calcify, this retards diffusion of Oz nutrients within the calcified matrix


Cartilage cell:


Mesenchyme stem( chondrogenic, chondroprogenitor) cells


Spindle undifferential cells • Derived from embryonic mesenchyme stem cell


Located incellular layer of perichondrium


differentiated in chondroblast


Chondroblast


Spindle immature cartilage cell


Differentiate into chondrocyte


Located between perichondrium and matrix Secretes type II collagen and other matrix


❖ Chondrocyte


Oval to round mature cartilage


It is chondroblast surrounded by matrix space(lacuna)


Young chondrocyte can divided but the adult chondrocyte cannot.


. Function:


Providing support with both elasticity and firmness


Forming the earliest skeleton in the fetus


Cartilage is essential for the development and growth of long bones before and after birth


• Embryology of cartilage


i. Cartilage arises from stem cells, and some mesenchyme cells aggregate to form a blastema


ii. Blastema cells secrete cartilage matrix and are called chondroblast


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