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Function:
Providing support with both elasticity and firmness
Forming the earliest skeleton in the fetus
Cartilage is essential for the development and growth of long bones before and after birth
o Embryology of cartilage
i. Cartilage arises from stem cells, and some mesenchyme cells aggregate to form a blastema
ii. Blastema cells secrete cartilage matrix and are called chondroblastChondrocyte
Oval to round mature cartilage
It is chondroblast surrounded by matrix space(lacuna)
Young chondrocyte can divided but the adult chondrocyte cannot..
It is tough, rigid, elastic and resilient tissue
• Divided into three type according to the nature of its matrix
Hyaline cartilage CT
Fibro cartilage CT
Elastic cartilage CT
• It grow, repair and regenerates slowly in adult because:
It hasn't vascular (BV, lymphatic) and hasn't nerve cell
O2 supply and nutrient diffuse from the perichondrium to cartilage cell in the matrix
Adult chondrocyte stop dividing and with age, the cartilage tends to be calcify, this retards diffusion of Oz nutrients within the calcified matrix
Cartilage cell:
Mesenchyme stem( chondrogenic, chondroprogenitor) cells
Spindle undifferential cells • Derived from embryonic mesenchyme stem cell
Located incellular layer of perichondrium
differentiated in chondroblast
Chondroblast
Spindle immature cartilage cell
Differentiate into chondrocyte
Located between perichondrium and matrix Secretes type II collagen and other matrix
❖ Chondrocyte
Oval to round mature cartilage
It is chondroblast surrounded by matrix space(lacuna)
Young chondrocyte can divided but the adult chondrocyte cannot.
. Function:
Providing support with both elasticity and firmness
Forming the earliest skeleton in the fetus
Cartilage is essential for the development and growth of long bones before and after birth
• Embryology of cartilage
i. Cartilage arises from stem cells, and some mesenchyme cells aggregate to form a blastema
ii. Blastema cells secrete cartilage matrix and are called chondroblast
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