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Vaccine safety by typeGenerally, all vaccines except live vaccines can be safely administered to pregnant women.Good examples are vaccines for attenuated oral polio andyellow fever.Mechanisms of maternal vaccination induced fetal and neonatal immune protectionMaternal vaccination generates both humoral and cell-mediated immune responses in the mother,protecting against infections, thereby reducing the risk of vertical transmission to the fetus.Immunoglobulin G (IgG) antibodies formed by the mother and transferred to the fetus via placentalcirculation (Fig.Livevaccines, on the other hand, are administered very selectively when there is imminent and substantialrisk of increased morbidity and mortality.2B).[2]
Vaccine safety by typeGenerally, all vaccines except live vaccines can be safely administered to pregnant women. Livevaccines, on the other hand, are administered very selectively when there is imminent and substantialrisk of increased morbidity and mortality. Good examples are vaccines for attenuated oral polio andyellow fever.Mechanisms of maternal vaccination induced fetal and neonatal immune protectionMaternal vaccination generates both humoral and cell-mediated immune responses in the mother,protecting against infections, thereby reducing the risk of vertical transmission to the fetus.Immunoglobulin G (IgG) antibodies formed by the mother and transferred to the fetus via placentalcirculation (Fig. 2A) as well as the mucosal IgG, IgA, and IgM antibodies, secreted into the colostrumand milk, protect the newborn in the postpartum period before it develops active immunity followingneonatal vaccination(Fig. 2B). [2]
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