Online English Summarizer tool, free and accurate!
Iron oxide nanoparticles (IONPs) have emerged as a promising alternative to con- ventional contrast agents (CAs) for magnetic resonance imaging (MRI).Here, the fundamental principles of MRI contrast agents are discussed, and the current status of MRI contrast agents is reviewed with a focus on the advantages and limitations of current T1 contrast agents and the potential of IONPs to serve as safe and improved alternative to gadolinium-based chelates.This review addresses key aspects in the development of IONPs for MRI applications, namely, synthesis of the inorganic core, functionalization processes to make IONPs biocom- patible and also to target them to specific tissues or cells, and finally in vivo studies in animal models, with special emphasis on tumor models.Thus, IONPs functionalized with epithelial growth factor receptor antibodies, short peptides, like RGD, or aptamers, among others, have been proposed for the diagnosis of various types of cancer, including breast, stomach, colon, kidney, liver or brain cancer.Furthermore, the ease of functionalization of their surfaces with different types of ligands (antibodies, peptides, sugars, etc.) opens up the pos- sibility of carrying out molecular MRI.Studies in developing IONPs as T1 contrast agents have generated promising results, but the complex, interrelated parameters influencing contrast enhancement make the development difficult, and IONPs suitable for T1 contrast enhancement have yet to make their way to clinical use.The past advances and current challenges in developing IONPs as a T1 contrast agent from a materials science perspective are presented, and how each of the key material properties and environment variables affects the performance of IONPs is assessed.They have been extensively investigated as CAs due to their high biocompatibility and excel- lent magnetic properties.Gadolinium-based chelates are a mainstay of contrast agents for magnetic resonance imaging (MRI) in the clinic.However, their toxicity elicits severe side effects and the Food and Drug Administration has issued many warnings about their potential retention in patients' bodies, which causes safety concerns.Iron oxide nanoparticles (IONPs) are a potentially attractive alternative, because of their nontoxic and biodegradable nature.
Iron oxide nanoparticles (IONPs) have emerged as a promising alternative to con- ventional contrast agents (CAs) for magnetic resonance imaging (MRI). They have been extensively investigated as CAs due to their high biocompatibility and excel- lent magnetic properties. Furthermore, the ease of functionalization of their surfaces with different types of ligands (antibodies, peptides, sugars, etc.) opens up the pos- sibility of carrying out molecular MRI. Thus, IONPs functionalized with epithelial growth factor receptor antibodies, short peptides, like RGD, or aptamers, among others, have been proposed for the diagnosis of various types of cancer, including breast, stomach, colon, kidney, liver or brain cancer. In addition to cancer diagnosis, different types of IONPs have been developed for other applications, such as the detection of brain inflammation or the early diagnosis of thrombosis. This review addresses key aspects in the development of IONPs for MRI applications, namely, synthesis of the inorganic core, functionalization processes to make IONPs biocom- patible and also to target them to specific tissues or cells, and finally in vivo studies in animal models, with special emphasis on tumor models.
Gadolinium-based chelates are a mainstay of contrast agents for magnetic resonance imaging (MRI) in the clinic. However, their toxicity elicits severe side effects and the Food and Drug Administration has issued many warnings about their potential retention in patients’ bodies, which causes safety concerns. Iron oxide nanoparticles (IONPs) are a potentially attractive alternative, because of their nontoxic and biodegradable nature. Studies
in developing IONPs as T1 contrast agents have generated promising
results, but the complex, interrelated parameters influencing contrast enhancement make the development difficult, and IONPs suitable for T1 contrast enhancement have yet to make their way to clinical use. Here, the fundamental principles of MRI contrast agents are discussed, and the current status of MRI contrast agents is reviewed with a focus on the advantages and limitations of current T1 contrast agents and the potential of IONPs to serve as safe and improved alternative to gadolinium-based chelates. The past advances and current challenges in developing IONPs as a T1 contrast agent from a materials science perspective are presented, and how each of the
key material properties and environment variables affects the performance of IONPs is assessed. Finally, some potential approaches to develop high- performance and clinically relevant T1 contrast agents are discussed.
Summarize English and Arabic text using the statistical algorithm and sorting sentences based on its importance
You can download the summary result with one of any available formats such as PDF,DOCX and TXT
ٌYou can share the summary link easily, we keep the summary on the website for future reference,except for private summaries.
We are working on adding new features to make summarization more easy and accurate
السلا السلام عليكم متابعين الكرام معكم السيد والنهاردة هبتدي معاكم كورس مهم جدا جدا وهو ال human re...
السريرة لو كُشِفَ للإنسان عن سريرة الإنسان لرأى منها ما يرى من غرائب هذا الكون وعجائبه، أَعْمَى أَدْ...
وكان التنسيق والتعاون الدائم مع الوزارات والهيئات ركيزة أساسية في دعم هذا النهج، بما يعزز من كفاءة ا...
العمل : صحفي ومستشار إعلامي سابق في الخارجية اليمنية ورئيس تحرير صحيفة هنا عدن الاخبارية ورئيس مركز ...
بين اليأس والرجاء صوتان لا بد أن يرتفعا في كل أمة ويجب أن يتوازنا حتى لا يطغى أحدهما على الآخر: صوت ...
إنه لشرف كبير لي أن أتولى رئاسة قسم بحوث أمراض القطن ومحاصيل الألياف بمعهد بحوث أمراض النباتات. يُعد...
وافق مجلس الشيوخ الأمريكي بفارق صوت واحد على مشروع قانون طرحه الرئيس دونالد ترامب لخفض الضرائب والإن...
لا يمكن تحديد مفهوم واضح ودقيق للأزمة ولا سيم بعد اتساع حدود انطباقه بمختلف العلاقات الإنسانية في كا...
لم أستطع أن أُكمل دراستي في تبوك لأني من الرياض، ولما بدأ الفصل الثاني دخلتُ فلم أجد خانة إدخال الطل...
إنجازات قسم بحوث أمراض الذرة والمحاصيل السكرية لقد حقق قسم بحوث أمراض الذرة والمحاصيل السكرية، منذ إ...
الآليات التربوية أولا: الآليات القانونية القانون الإداري يعد القانون الإداري المغربي من الأدوات الرئ...
الموافقة على مخاطر تكنولوجيا المعلومات. بناءً على حدود تحمل المخاطر الخاصة بتكنولوجيا المعلومات الم...