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Powder moisture content of a dried substance varies from product to product.For substances appearing to contain water as the only volatile constituent, the method of Loss on Drying (LOD) is widely applied within the pharmaceutical production as a practical in process control procedure.Principles of Moisture Determination by Los on Drying Method (LOD) Moisture content of a sample is determined by heating the sample to dryness and then calculating the moisture loss.Moisture Determination Balances provide a primary method of moisture analysis by using the loss on drying (LOD) method.A solid (dry powder or wet granulation) sample is placed in the sample pan
Powder moisture content of a dried substance varies from product to product.
Moisture content analysis is a critical component of material quality and
essentially a function of quality control in most production and laboratory
facilities.
In the pharmaceutical industry, the moisture content is considered critical
parameter in determining number of physical-chemical characteristics.
Powder flow, powder compressibility and chemical stability of the active
pharmaceutical ingredient are some of the critical attributes that might be affected
by moisture.
The procedure set forth in this laboratory experiment determines the amount of
volatile matter of any kind that is driven off under the conditions specified.
For substances appearing to contain water as the only volatile constituent, the
method of Loss on Drying (LOD) is widely applied within the pharmaceutical
production as a practical in process control procedure.
Principles of Moisture Determination by Los on Drying Method (LOD)
Moisture content of a sample is determined by heating the sample to dryness
and then calculating the moisture loss. The calculations used to arrive at a
result are based on weights taken before and after drying the sample.
Moisture Determination Balances provide a primary method of moisture
analysis by using the loss on drying (LOD) method.
A solid (dry powder or wet granulation) sample is placed in the sample pan
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