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The SSRIs and 5-HT2A antagonists are represented by trazodone
The structures of this compound derive from those of the fluorobutyrophenone antipsychotics.In this compound, the additional hydrophobic substituent can be viewed as being attached to the nitrogen of the ?-arylamine-like group.It has ?-arylamine-like structures that permit binding to the SERT and inhibit 5-HT reuptake.Additionally, it is 5-HT2A antagonists.
The SSRIs and 5-HT2A antagonists are represented by trazodone
The structures of this compound derive from those of the fluorobutyrophenone antipsychotics.
It has β-arylamine–like structures that permit binding to the SERT and inhibit 5-HT reuptake.
In this compound, the additional hydrophobic substituent can be viewed as being attached to the nitrogen of the β-arylamine–like group.
Additionally, it is 5-HT2A antagonists.
5-HT2A antagonist appears to have antidepressant and anxiolytic activities. It may act, at least in part, by enhancing 5-HT1A activities.
Also, some of the effects may be mediated through 5-HT2C agonism (perhaps generally so for 5-HT–acting antidepressants).
Some of the side effects of SSRIs are considered to be mediated through 5-HT2A receptors, so a 5-HT2A blocker would reduce them.
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