Online English Summarizer tool, free and accurate!
Laboratory features
12
POLYCYTHAEMIA RUBRA VERA
oBone marrow is hypercellular with prominent megakaryocytes, iron stores are depleted because of excessive iron incorporation into red cells and the trephine biopsy may show mildly increased reticulin.oSecondary or reactive polycythaemia may occur in conditions where arterial oxygen saturation is reduced, leading to a physiological rise in serum EPO, or when EPO levels are inappropriately raised (e.g. caused by secretion of EPO by a renal neoplasm or other turmour).Differential diagnosis
14
POLYCYTHAEMIA RUBRA VERA
oThrombosis is the main cause of morbidity and mortality and its incidence can be reduced by maintaining the PCV below 0.45 and platelets below 600 x 109 /L.oCulture of peripheral blood cells shows spontaneous formation of erythroid colonies in the absence of exogenous EPO.
Laboratory features
12
POLYCYTHAEMIA RUBRA VERA
•Bone marrow is hypercellular with prominent megakaryocytes, iron stores are depleted because of excessive iron incorporation into red cells and the trephine biopsy may show mildly increased reticulin.
•Abdominal ultrasound excludes renal disease and assesses spleen size.
•Culture of peripheral blood cells shows spontaneous formation of erythroid colonies in the absence of exogenous EPO.
Laboratory features
13
POLYCYTHAEMIA RUBRA VERA
•The JAK2 mutation is absent in all other forms of polycythaemia.
•Secondary or reactive polycythaemia may occur in conditions where arterial oxygen saturation is reduced, leading to a physiological rise in serum EPO, or when EPO levels are inappropriately raised (e.g. caused by secretion of EPO by a renal neoplasm or other turmour).
•Serum EPO measurement is indicated.
Differential diagnosis
14
POLYCYTHAEMIA RUBRA VERA
•Thrombosis is the main cause of morbidity and mortality and its incidence can be reduced by maintaining the PCV below 0.45 and platelets below 600 x 109 /L. Aspirin (75mg daily) is often used to inhibit platelet function.
•Multiple venesections are used initially to lower the PCV and in some cases for long-term treatment.
•Chemotherapy (e.g. oral hydroxyurea) is also usually required.
•Specific JAK2-inhibiting drugs are in clinical trial.
•A proton pump inhibitor is used for patients with indigestion or history of gastrointestinal bleeding.
•Allopurinol is used to prevent hyperuricaemia.
Treatment
15
POLYCYTHAEMIA RUBRA VERA
•Median survival is about 16 years.
•Up to 30% of patients develop myelofibrosis.
•Acute myeloid leukaemia occurs in up to 5% of patients, not increased by hydroxycarbamide.
Prognosis
16
Summarize English and Arabic text using the statistical algorithm and sorting sentences based on its importance
You can download the summary result with one of any available formats such as PDF,DOCX and TXT
ٌYou can share the summary link easily, we keep the summary on the website for future reference,except for private summaries.
We are working on adding new features to make summarization more easy and accurate
تؤكد النظرية الإنسانية في الاستشارة الزوجية على أهمية النمو الشخصي، والوعي الذاتي، وتحقيق إمكانات كل...
مهارات االتصال واستكشاف األخطاء وإصالحها والسلوك المهني العلاقه بين مهارات االتصال واستكشاف األخطا...
واجه العديد من الأشخاص مشاكل في فهم شخص آخر من بلد آخر ولغة ومجتمع آخر، بالإضافة إلى لقاءات في الشرك...
1. تواصل غير فعال: قد يواجه المراهقون صعوبة في التواصل مع والديهم بشكل فعّال، مما قد يؤدي إلى سوء ا...
Thermal analysis techniques are those in which a physical property of a substance or its reaction pr...
في مساء يوم الاثنين شعرت ماريلا بالضيق لأنها لم ترى مشبك الجمشت وبحثت عنه في كل مكان ولكن لم تعثر عل...
Contents 1. Plan and prepare for meetings 2. Conduct meetings 3. Debrief and follow up meetings. Un...
3. القصة ونحن ندلف إلى هذا العمل المتميز الروائي متميز هو الآخر وقد مضى في مسيرته الكتابة باللغة ال...
?" ! The narrator in *Lord of the Flies* is a separate, unnamed, impar9al narrator is aware of what ...
السرد إعلان مناخ مناسب للتعبير عن التجارب والمعاناة التي واجهها الشاعر بتضمينه صوراً شعرية عريضة ...
Step 6: Monitoring and Evaluating Performance Monitoring and evaluating performance require ongoing ...
في تناول الموضوعات التربوية والخلقية التي اختارها لكتابتها ، فلقيت مقالاته رواجا كبيرا في أوساط الق...