Online English Summarizer tool, free and accurate!
The synthesis of thiophenic compounds, previously identified in Tagetes patula, revealed that 4-(5?Based on the affinity score (GlideScore = -5.7 kcal.mol- 1
) and the proposed binding mode,
Thio1 could be classified as a potential GluCl ligand, justifying the promising results observed in the anthelmintic
assays.-bithiophene]-5-yl)but-3-yn-1-ol), or simply Thio1, has a pronounced in vitro anthelmintic effect
against Haemonchus contortus, showing 100% efficacy in the egg hatch and larval development tests presenting
EC50 = 0.1731 mg.mL- 1 and EC50 = 0.3243 mg.mL- 1
, respectively.-(hydroxymethyl)-[2,2?
The synthesis of thiophenic compounds, previously identified in Tagetes patula, revealed that 4-(5′
-(hydroxymethyl)-[2,2′
-bithiophene]-5-yl)but-3-yn-1-ol), or simply Thio1, has a pronounced in vitro anthelmintic effect
against Haemonchus contortus, showing 100% efficacy in the egg hatch and larval development tests presenting
EC50 = 0.1731 mg.mL− 1 and EC50 = 0.3243 mg.mL− 1
, respectively. So, this compound was selected to preparation of a nanostructured formulation to be orally administered to Santa Inˆes sheep. In general, from the fecal
egg count reduction test (FECRT), it was observed that the product kept the parasitic load in the digestive tract of
the hosts stable, with eggs per gram of faeces (EPG) counts having a mean value < 3,000 (EPGmean = 2167.1,
efficacy = 36,45%), thus protecting the animals from health risks caused by a massive nematode infestation. To
better understand the mode of action of this thiophene derivative, in silico molecular modeling studies were
carried out with the glutamate-activated chloride channel (GluCl), a well-known molecular target of anthelmintic compounds. Based on the affinity score (GlideScore = -5.7 kcal.mol− 1
) and the proposed binding mode,
Thio1 could be classified as a potential GluCl ligand, justifying the promising results observed in the anthelmintic
assays.
Summarize English and Arabic text using the statistical algorithm and sorting sentences based on its importance
You can download the summary result with one of any available formats such as PDF,DOCX and TXT
ٌYou can share the summary link easily, we keep the summary on the website for future reference,except for private summaries.
We are working on adding new features to make summarization more easy and accurate
Successful organizations understand that strategy is not a one-time endeavor but rather an ongoing j...
موضوعات الكتب مجموعات هنداوي السلاسل والأعمال الكاملة حضارة العرب ePub Logo PDF Logo Kindle Logo الف...
الحقيقة حول اضطرابات الأكل على مدى العقدين الماضيين، أصبحنا أكثر وعيا بمخاطر اضطرابات الأكل. اثنا...
Disadvantages and contraindications of first molar extraction Additional studies have investigated t...
إن التفكير بالعولمة، في بعدها الثقافي، يكشف أيضا طبيعتها الديالكتيكية في الأساس على نحو بالغ الوضوح....
Heat Assisted Magnetic Recording (HAMR) is a technology developed to significantly increase the amou...
Nine year old Arnold and his older brother Eugie set out to pick peas and potentially shoot ducks. W...
تعزيز الحرف اليدوية والثقافة المحلية : يساهم الموقع في دعم الحرفيين المحليين وتعزيز الحرف اليدوية وا...
- حل مشكله عدم توفر موقع جامع للحرفيين و أسعار معقولة في متناول الجميع ونشر الوعي في المجتمع ويساهم ...
-استراتيجية الإدعاء العام وتعمل على التركيز على إدعاء عام أو فائدة أساسية في المنتج. -استراتيجية الد...
يُظهر الفكرة الأولمبية، التي تجسدت في القرون الماضية." ونشرت كل الصحف اليونانية حديثه، فهب الشعب الي...
يقول ابن خلدون : ه بما أن الخليفة هو الناظر في مصالح الامة الدينية والدنيوية وهو وليها والامين عليه...