Online English Summarizer tool, free and accurate!
The synthesis of thiophenic compounds, previously identified in Tagetes patula, revealed that 4-(5′
-(hydroxymethyl)-[2,2′
-bithiophene]-5-yl)but-3-yn-1-ol), or simply Thio1, has a pronounced in vitro anthelmintic effect
against Haemonchus contortus, showing 100% efficacy in the egg hatch and larval development tests presenting
EC50 = 0.1731 mg.mL− 1 and EC50 = 0.3243 mg.mL− 1
, respectively. So, this compound was selected to preparation of a nanostructured formulation to be orally administered to Santa Inˆes sheep. In general, from the fecal
egg count reduction test (FECRT), it was observed that the product kept the parasitic load in the digestive tract of
the hosts stable, with eggs per gram of faeces (EPG) counts having a mean value < 3,000 (EPGmean = 2167.1,
efficacy = 36,45%), thus protecting the animals from health risks caused by a massive nematode infestation. To
better understand the mode of action of this thiophene derivative, in silico molecular modeling studies were
carried out with the glutamate-activated chloride channel (GluCl), a well-known molecular target of anthelmintic compounds. Based on the affinity score (GlideScore = -5.7 kcal.mol− 1
) and the proposed binding mode,
Thio1 could be classified as a potential GluCl ligand, justifying the promising results observed in the anthelmintic
assays.
The synthesis of thiophenic compounds, previously identified in Tagetes patula, revealed that 4-(5′
-(hydroxymethyl)-[2,2′
-bithiophene]-5-yl)but-3-yn-1-ol), or simply Thio1, has a pronounced in vitro anthelmintic effect
against Haemonchus contortus, showing 100% efficacy in the egg hatch and larval development tests presenting
EC50 = 0.1731 mg.mL− 1 and EC50 = 0.3243 mg.mL− 1
, respectively. So, this compound was selected to preparation of a nanostructured formulation to be orally administered to Santa Inˆes sheep. In general, from the fecal
egg count reduction test (FECRT), it was observed that the product kept the parasitic load in the digestive tract of
the hosts stable, with eggs per gram of faeces (EPG) counts having a mean value < 3,000 (EPGmean = 2167.1,
efficacy = 36,45%), thus protecting the animals from health risks caused by a massive nematode infestation. To
better understand the mode of action of this thiophene derivative, in silico molecular modeling studies were
carried out with the glutamate-activated chloride channel (GluCl), a well-known molecular target of anthelmintic compounds. Based on the affinity score (GlideScore = -5.7 kcal.mol− 1
) and the proposed binding mode,
Thio1 could be classified as a potential GluCl ligand, justifying the promising results observed in the anthelmintic
assays.
Summarize English and Arabic text using the statistical algorithm and sorting sentences based on its importance
You can download the summary result with one of any available formats such as PDF,DOCX and TXT
ٌYou can share the summary link easily, we keep the summary on the website for future reference,except for private summaries.
We are working on adding new features to make summarization more easy and accurate
• Most of the drugs have specific patent life. Strategy formulation for new drugs and generic medici...
و لعل أهم ما يميز هذه الحقبة هو ظهور لغة (JAVA) التي تحوي - دعماً خاصاً لكي تنفذ من خلال الويب و هي ...
لیوم ھو السادس من ديسمبر 2017 .لم أتناول إفطاري حتى الساعة ّد ُت تعو على الحادية عشرة صباحاً؛ كن ُت ...
يعتبر الجرجير مصدراً نباتيّاً غنيّاً بمضاداّت الأكسدة، كما أنّه مدرٌ للبول، ويساعد في عملية الهضم، و...
Overview The Institute of Medicine has identifi ed three core functions of public health that recog...
التكاثر هو إحدى العمليات الحيوية التي تؤمن إنتاج متعضيات جديدة تؤمن استمرار النوع الحي. التكاثر إحدى...
لما تفرّغ ألب أرسلان من ضم مدنه وتثبيت أركان دولته، وخاصة بعدما فتح جورجيا وأرمينيا، خشي قيصر دولة ا...
İş dünyasında işler bazen planlandığı gibi gitmeyebilir. Ürün ve hizmetlerde kalite tutturulamayabil...
1. اختيار أئمة التنمية على مستوى المحافظات (على الأقل عدد 2 من الدعاة المدربين في كل مركز، ويكونوا خ...
يختلف حجم الهجرة داخل إقليم معين باختلاف درجة الغواص- مدينة المناطق المدرجة في تلك المنطقة. 2. يخت...
Last night was the first semi final of the men's National Open Tennis Championship in Toronto, Canad...
The purpose of this paper is to investigate the performance of starch in potable water treatment and...