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A major Baltimore bridge collapsed early Tuesday after it was hit by a large container ship.The missing people may have fallen into the water.The bridge carries Interstate 695 across the Patapsco River, southeast of the Baltimore metropolitan area.Wiedefeld said the incident is an active search and rescue mission and that vessel traffic into and out of the Port of Baltimore is suspended until further notice.This is a very large incident, it involves a very large footprint," Baltimore City Fire Department Chief James W. Wallace said in a press briefing. The National Transportation Safety Board launched a team to investigate the collapse, a spokesperson told CNBC.Sonar scans detected the presence of submerged vehicles, but could not disclose the number of cars involved, the fire department chief said. Asked if the ship was suffering any technical impairments, he said, "We do not have that information."Six people were missing after the collision at the Francis Scott Key Bridge, according to Paul Wiedefeld, Maryland's transportation secretary.The crash by the large container ship occurred around 1:30 a.m. ET, when contractors were working on the bridge, according to Wiedefeld."We are going to make sure that this is not just not just rebuilt, but that we are going to rebuild in a way that remembers the people who this tragedy has impacted," Moore said."We haven't seen any credible evidence of a terrorist attack."

A major Baltimore bridge collapsed early Tuesday after it was hit by a large container ship.

Six people were missing after the collision at the Francis Scott Key Bridge, according to Paul Wiedefeld, Maryland’s transportation secretary. Two people were rescued, with one transported to a trauma center in serious condition. The missing people may have fallen into the water.The bridge carries Interstate 695 across the Patapsco River, southeast of the Baltimore metropolitan area.

The crash by the large container ship occurred around 1:30 a.m. ET, when contractors were working on the bridge, according to Wiedefeld. The missing people are believed to be the construction crew who were repairing potholes on the bridge.

Wiedefeld said the incident is an active search and rescue mission and that vessel traffic into and out of the Port of Baltimore is suspended until further notice.This is a very large incident, it involves a very large footprint,” Baltimore City Fire Department Chief James W. Wallace said in a press briefing.

The National Transportation Safety Board launched a team to investigate the collapse, a spokesperson told CNBC.Sonar scans detected the presence of submerged vehicles, but could not disclose the number of cars involved, the fire department chief said.

“The latest information we have on the crew of the ship is that they still are on board of the ship,” Wallace said, adding that rescue agents must first do a damage assessment of the vessel before being able to board. Asked if the ship was suffering any technical impairments, he said, “We do not have that information.”

Maryland officials and the FBI said there is no information to suggest the collapse was a result of terrorism.The preliminary investigation points to an accident,” said Maryland Gov. Wes Moore. “We haven’t seen any credible evidence of a terrorist attack.”

Completed in 1977, the bridge took the name of Francis Scott Key, whose poem was the foundation of the U.S. national anthem.

About 35,000 people use the bridge every day, according to Wiedefeld. Drivers in the area will have to use the far-busier Baltimore Harbor and Fort McHenry tunnels to cross the harbor for the foreseeable future.Moore said the priority now is on search and rescue, but that the rebuilding of the bridge will be a long-term project.

“We are going to make sure that this is not just not just rebuilt, but that we are going to rebuild in a way that remembers the people who this tragedy has impacted,” Moore said.