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Oral paracetamol has excellent bioavailability with peak plasma concentrations occurring within 30-60 min after ingestion; the plasma t1/2 is about 120 min.Paracetamol is principally transformed into inactive compounds through the conjugation with sulfate and glucuronide, and a small portion is oxidized via the cytochrome P450 enzyme system (its CYP2E1 and CYP1A2 isoenzymes).Its binds to plasma proteins less than NSAIDs and diffuses throughout most body fluids.
Oral paracetamol has excellent bioavailability with peak plasma concentrations occurring within 30–60 min after ingestion; the plasma t1/2 is about 120 min. Its binds to plasma proteins less than NSAIDs and diffuses throughout most body fluids. The kidneys excrete glucuronide conjugates. Some 90–100% of the drug may be recovered in the urine within the first day at therapeutic dosing [18,19]. Paracetamol is principally transformed into inactive compounds through the conjugation with sulfate and glucuronide, and a small portion is oxidized via the cytochrome P450 enzyme system (its CYP2E1 and CYP1A2 isoenzymes). The CYP2E1 and CYP1A2 convert paracetamol into the alkylating metabolite (N-acetyl-p-benzoquinone imine,
NAPQI), which may be responsible for paracetamol liver toxicity (see also Section 6. Safety and
Toxicity). Based on the levels of CYP2D6 expression, individuals can be classified into
“extensive”, “ultrarapid”, and “poor metabolizers”
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